abcollie Posted January 25, 2012 Report Share Posted January 25, 2012 A friend of mine has a dog that just went deaf from it and I was wondering if anyone knows how the research is going? This is really heartbreaking for both her and the dog :@( Thanks. Quote Link to comment Share on other sites More sharing options...
Liz P Posted January 25, 2012 Report Share Posted January 25, 2012 Gene identified, commercial test is being developed but needs more testing before it is released. Have your friend send in samples for the study. Sorry for your friend. It's heartbreaking to get a dog trained up then lose it to a health problem like that. I know from personal experience. Quote Link to comment Share on other sites More sharing options...
Journey Posted January 25, 2012 Report Share Posted January 25, 2012 Samples? Are they responding to requests yet? Quote Link to comment Share on other sites More sharing options...
Liz P Posted January 25, 2012 Report Share Posted January 25, 2012 They have been, but it can be tricky to get in touch with them. Quote Link to comment Share on other sites More sharing options...
Sue R Posted January 25, 2012 Report Share Posted January 25, 2012 I emailed (to this group - dogdna@tgen.org), got a response about a month and a half later (they had received such an overwhelming response that they had lost a few emails), received the test swabs, and sent them back. This was in March 2011. Our Megan was tested normal at age 2 (BAER test) and began losing hearing around age 5. She was completely deaf apparently, and by BAER test, by the age of 7. It will be great to have better information about this issue and have a test for it. I'm assuming you are talking about the same group. Quote Link to comment Share on other sites More sharing options...
abcollie Posted January 26, 2012 Author Report Share Posted January 26, 2012 I emailed (to this group - dogdna@tgen.org), got a response about a month and a half later (they had received such an overwhelming response that they had lost a few emails), received the test swabs, and sent them back. This was in March 2011. Our Megan was tested normal at age 2 (BAER test) and began losing hearing around age 5. She was completely deaf apparently, and by BAER test, by the age of 7. It will be great to have better information about this issue and have a test for it. I'm assuming you are talking about the same group. They were "overwhelmed" is a VERY scary thought. Does anyone have any idea how wide spread this is? Quote Link to comment Share on other sites More sharing options...
Journey Posted January 26, 2012 Report Share Posted January 26, 2012 They were "overwhelmed" is a VERY scary thought. Does anyone have any idea how wide spread this is? My kits never showed up and I found out I wasn't alone. If you think scary is them overwhelmed then *I* think *nightmare* may be on the horizon.... Quote Link to comment Share on other sites More sharing options...
Liz P Posted January 26, 2012 Report Share Posted January 26, 2012 If you think scary is them overwhelmed then *I* think *nightmare* may be on the horizon.... Yes, that does seem to be a real possibility. For example, if just 1% of dogs are affected, that makes 10% of dogs carriers. I wish the people involved in the study would at least give us an idea of their best estimate for carrier rate in the population. Quote Link to comment Share on other sites More sharing options...
workindogs Posted January 26, 2012 Report Share Posted January 26, 2012 They contacted me because my name was on the other databases (since I've contributed to the Epilepsy, etc).....I agreed to test all my dogs (7), they said that they'd send the kits but the kits never arrived. Yes, I'd love to hear more about the progress they've made....could be very very interesting...from my POV more worthwhile than EIC. Quote Link to comment Share on other sites More sharing options...
Sue R Posted January 26, 2012 Report Share Posted January 26, 2012 You know, I'm sitting here with my old lady brain (otherwise known as what little remains of my younger woman brain) and wondering if I actually did get the test kits or not. I have the email that says they were going out "on Monday" but I'm wondering if I'm confusing these kits with the ones that I did get from Melanie's study (noise sensitivity and genome) several years back. A mind is a terrible thing to lose. Quote Link to comment Share on other sites More sharing options...
Mark Billadeau Posted January 26, 2012 Report Share Posted January 26, 2012 All, I've been trying to get an update from Mark Neff for several months. I just sent another email to him and his admin assistant which includes a link to this thread. I will try getting him on the phone this week. I feel your frustration. Mark Quote Link to comment Share on other sites More sharing options...
abcollie Posted January 26, 2012 Author Report Share Posted January 26, 2012 All, I've been trying to get an update from Mark Neff for several months. I just sent another email to him and his admin assistant which includes a link to this thread. I will try getting him on the phone this week. I feel your frustration. Mark Is there anyone else working on it? ABCA? Anyone we could get in touch with and encourage them to work on it? Quote Link to comment Share on other sites More sharing options...
Mark Billadeau Posted January 26, 2012 Report Share Posted January 26, 2012 Candy, I have gotten the message loud and clear. Mark Billadeau ABCA Health & Genetics Committee Chair Quote Link to comment Share on other sites More sharing options...
abcollie Posted January 26, 2012 Author Report Share Posted January 26, 2012 Candy, I have gotten the message loud and clear. Mark Billadeau ABCA Health & Genetics Committee Chair Thanks :@) Quote Link to comment Share on other sites More sharing options...
Journey Posted January 26, 2012 Report Share Posted January 26, 2012 Candy, I have gotten the message loud and clear. Mark Billadeau ABCA Health & Genetics Committee Chair Maybe she was just making sure you don't have EOD Quote Link to comment Share on other sites More sharing options...
abcollie Posted January 26, 2012 Author Report Share Posted January 26, 2012 Maybe she was just making sure you don't have EOD Wouldn't that be EOR (early onset reading :@) I just wasn't sure if "that" research group was sponsored by ABCA --- or was an independent group? Either way I feel better knowing Mark is working on it. Quote Link to comment Share on other sites More sharing options...
Sue R Posted January 26, 2012 Report Share Posted January 26, 2012 Either way I feel better knowing Mark is working on it. Yes! Quote Link to comment Share on other sites More sharing options...
backtoblack Posted April 17, 2012 Report Share Posted April 17, 2012 Any update on the availability of this test? Thanks Quote Link to comment Share on other sites More sharing options...
Mark Billadeau Posted April 18, 2012 Report Share Posted April 18, 2012 EOD Status: The region of the genome where the mutation is located has been conclusively identified (this was reported at the VA finals). The region is 3 million base pairs in the 2500 million base pair canine genome. The next set of tests they ran typically reveals the exact location of the suspected mutation and with this information they can develop a test. What actually happened is the next set of experiments was not able to find the exact location of the mutation. They proposed reasons why they were not able to identify the exact location of the mutation; the most likely is related to the current state of the genetic testing technology and the exact size a location of the mutation. Additional (costly) experiments are being evaluated (in terms of likely success and/or possible benefit to breeders) as a means to aid in locating the mutation; meanwhile, genetic testing technology continues to improve. Quote Link to comment Share on other sites More sharing options...
Pam Wolf Posted April 18, 2012 Report Share Posted April 18, 2012 Even though the testing is being carried out we need to be open about this issue. it is a problem that is more widespread than most people think. We need to stop covering up the problem with excuses such as i shot a gun over the dog's head and therefore he is deaf, or he got kicked in the head and therefore he is deaf. Be open, sure there are those who will condem, but if there is any suspicion that the dog has EOD PLEASE Do not breed them, there are still enough good dogs to not introduce a major problem like this further into the breed. Quote Link to comment Share on other sites More sharing options...
abcollie Posted April 18, 2012 Author Report Share Posted April 18, 2012 EOD Status: The region of the genome where the mutation is located has been conclusively identified (this was reported at the VA finals). The region is 3 million base pairs in the 2500 million base pair canine genome. The next set of tests they ran typically reveals the exact location of the suspected mutation and with this information they can develop a test. What actually happened is the next set of experiments was not able to find the exact location of the mutation. They proposed reasons why they were not able to identify the exact location of the mutation; the most likely is related to the current state of the genetic testing technology and the exact size a location of the mutation. Additional (costly) experiments are being evaluated (in terms of likely success and/or possible benefit to breeders) as a means to aid in locating the mutation; meanwhile, genetic testing technology continues to improve. Thanks for the info Mark. So, in "layman" terms? It's a mutation but they can't find where it's coming from (and won't be able to until genetic testing improves). So ... does that mean it's like the lottery (the losing kind :@( where it just turns up because something mutates? Both parents have it or they just don't know? Thanks for keeping up with this ... it's frustrating for people to put so much time/effort/energy into their dogs and have them go deaf just when they are trained. Quote Link to comment Share on other sites More sharing options...
backtoblack Posted April 18, 2012 Report Share Posted April 18, 2012 Thanks for the update. Quote Link to comment Share on other sites More sharing options...
Sue R Posted April 18, 2012 Report Share Posted April 18, 2012 Thank you, Mark! Quote Link to comment Share on other sites More sharing options...
Mark Billadeau Posted April 19, 2012 Report Share Posted April 19, 2012 Candy, They know the mutation is within the 3 million base pair region and it is recessive (like CEA); where the dog can be clear (2 normal genes), carrier (1 mutated gene 1 normal gene), and affected (2 mutated genes). There may be another gene (or genes) which modifies when the dog goes deaf. These are huge steps forward. My personal recommendation (unofficially) is until we know more, genetically, we should treat the breeding of EOD lines like we did before there was a DNA test for CEA: don't breed affected dogs, be VERY careful (or don't) cross affected lines (dogs could be carriers), and share information which may help determine which dogs could be carriers. We will find the gene(s) responsible for EOD, I just don't know when. Mark Too bad you're not on this side of the country, we had (all banded now) some REALLY flashy Katahdin ram lambs this year (chocolate & white spotted, tan & white spotted, and a nice set of triplets that were black with white spots). Quote Link to comment Share on other sites More sharing options...
Kerales Farm Posted April 19, 2012 Report Share Posted April 19, 2012 Mark, are you saying that it is a simple recessive, rather than a polygenic? Quote Link to comment Share on other sites More sharing options...
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