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Mark Billadeau

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Everything posted by Mark Billadeau

  1. Sallie Butler has been running kelpies in NEBCA & USBCHA trials for several years.
  2. I’ve not seen and new studies in dogs. The previously posted studies indicated dogs can be infected (from infected humans or in a small virus challenge study). The dogs in the challenge study did not shed virus (were unlikely to transmit the virus to other dogs or humans).
  3. This study was performed at the Biosecurity Research Institute at KSU and it was definitely not a gain of function study; the virus was not manipulated to alter the virus. The animals were just exposed to the virus.
  4. Susceptibility of sheep to experimental co-infection with the ancestral lineage of SARS-CoV-2 and its alpha variant BioRxiv preprint 17 Nov 2021 Sheep did become infected after a direct challenge of virus (Wuhan or Wuhan plus Alpha variants); however, the sheep not challenged with virus but house with the challenged sheep did not become infected. This was a very small study, only 10 sheep.
  5. The cea test, as far as I know, has always been for the causative mutation. Go reread the statement the HEF put out on this test.
  6. I do not know if editors and reviewers of genetic journals believe if these types of genetic tests and the supporting data are worthy of being published. I (and others not in the field of genetic research) will have to trust those in the field to answer that question.
  7. No causative mutation has been found to be published.
  8. Where did you get the idea that the agreement between HEF and Lohi is nullified? When there is new information that we can share; it will be posted.
  9. There is a study out of Israel which found a 20 percentage point increase in vaccination rates correlated to a 2x reduction in infections in those who cannot be vaccinated.
  10. This study was conducted using one of our products Antibody levels predictive of Moderna's vaccine efficacy -study My employer has returned to mandatory mask use.
  11. Not new research, ongoing research running down leads towards identifying the causative mutation(s). Beyond this I am not at liberty to discuss because of the confidentiality agreement (common practice in research) established at the onset of the research.
  12. No new info, getting owners to bring in their dogs for a research study during covid has proven challenging
  13. Here is a link to the published study Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis
  14. Rookies are generally younger seniors being considered younger may not be that bad
  15. Take your dog’s temperature. https://vcahospitals.com/know-your-pet/taking-your-pets-temperature
  16. Depends on the dog! Our first loved fetch. He was so driven to fetch he impaled himself on a bush branch diving into the bushes to get the ball. He kept playing fetch (no signs of pain) until we noticed the hole in his back. He also cut open his front leg (we guess on broken glass in the bushes) and didn’t stop until we saw the blood. His drive was present working stock or any other activity; pain would not dampen his drive. It fell upon us to protect him from his drive. Some of our dogs have been careful to protect their bodies playing or working stock; while others were driven enough to require us to moderate their drive in risky situations. The risks of injury were less about the activity and more about the personality of the dog.
  17. Another resource is the Ontario Border Collie Club
  18. I’ve seen a few published studies on human genes that impact how fast drugs are absorbed from a transdermal patch. Perhaps, there are analogous canine mutations (with very low incident rates) that alter how fast drugs delivered to the skin of dog via spot-on or slow release collars are absorbed through the skin into the bloodstream. If the serum levels get high enough most drugs can become toxic.
  19. Go compare the dose per kg for ivermectin for oral, IM, and pour on for treatment of the same parasite. The route of introducing a drug impacts the resulting serum levels. Working backwards from this information one learns that how one is exposed to an active ingredient alters the amount one can tolerate before it becomes toxic. Also the magnitude of the dose/time impacts the resulting serum levels; slow release from a collar vs spray coated with a liquid. This publication describes how the slow release collars work. The discussion section has a good overview. The synergistic action of imidacloprid and flumethrin and their release kinetics from collars applied for ectoparasite control in dogs and cats
  20. While the active ingredient in these collars may be causing reactions at the dose being provided by the collars; the example above has a flaw. The dose/exposure obtained while spraying will be higher and the possibly routes of body entry (inhalation, eyes, absorption through the skin, etc) will be more than from a collar. If one were to exclude active ingredients based upon the required protection during agricultural spraying one would also need to exclude soap; agricultural spraying “insecticidal soap” also requires hazmat gear.
  21. I’m sorry I don’t have any information for you on a connection between seizures and what you described.
  22. My employer has been designated as “essential”; which means I’m in the current group being vaccinated and am waiting to hear when new doses are available.
  23. Please excuse me while I brag on my employer. Here is part of a press release from my employer on products we developed with NIAID (Dr Fauci’s department) to measure the antibodies against SARS-CoV-2: ”Operation Warp Speed (OWS) has chosen as the basis of its standard binding assays for immunogenicity assessments in all funded Phase III clinical trials of vaccines.” Our product was and is being used for several vaccines being tested and data has been published for Moderna’s and AstraZeneca’s vaccines using our product.
  24. Dogs are able to digest and utilize the nutrients in corn meal (and other grains). Proven in studies where only corn meal is fed and measuring the differences between the nutrients in the feed and what comes out after digestion; also proven by the presence of multiple copies of amylase genes in dogs which produces enzymes that digest the starch from grains. Grains are not good for dogs that have allergies to those grains. Species specific meat meals are manufactured from what usda slaughter houses (animals must be able to walk in on their own power to meet usda inspection) provide because of how much raw ingredients the rendering process needs (this equipment processes 2-16 tons/hr https://mavitecrendering.com/rendering-equipment/processing-section/supercookor/); obtaining species specific carcasses from low volume sources would be disruptive to their supply chain (no one could sort animal parts by species when they arrive at a rendering plant). Species can be (and have been) identified in meat meals (or kibble) by dna testing. Non species specific meat meals likely utilize non usda inspected sources.
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