gcv-border Posted January 19, 2022 Report Share Posted January 19, 2022 Denise MaherScottish-Collie Resource Page Stmeptem2hb0er 188,3t 20218ed · IMPORTANT MDR1 UPDATE It has been officially confirmed that MDR1 which is a genetic mutuation (MDR1 is the abbreviated name of a gene called Multi-Drug Resistance 1) that causes sensitivity to Ivermectin and a number of other drugs in many herding breeds is determined to be AUTOSOMAL DOMINANT. This means that dogs need only carry one mutuant gene to be affected. Dogs will now be listed as carrier/affected rather than just carrier if they possess only one gene for MDR1. Dogs with the mutation will react to certain drugs including Ivermectin. Whether a dog reacts depends on the dosage of the drug. A dog may not react to very low doses, as with the amount of Ivermectin found in heart worm products for dogs but dosages used for livestock are highly toxic. Typical doses of a variety of medications will cause reactions in dogs with two copies of the mutation, but some drugs – most notably several chemotherapy agents – can cause reactions in dogs with only one. Dogs with this mutation have a transport defect—the drug goes in to their brains, fails to be transported out, and builds up to toxic levels. This causes serious neurological problems including seizures or death in many herding breeds to include collies. Please treat all carriers of MDR1 as affected. Reference: http://www.ashgi.org/home-page/genetics-info/faq/mdr1-faqs Quote Link to comment Share on other sites More sharing options...
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