Orange Oil

[Journey]

I found this article and am wondering if anyone has tried Orange Oil?

 

Vet Parasitol. 2010 Apr 18. [Epub ahead of print]

Efficacy of an orange oil emulsion as an anthelmintic against Haemonchus contortus in gerbils (Meriones unguiculatus) and in sheep.

 

Squires JM, Foster JG, Lindsay DS, Caudell DL, Zajac AM.

 

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061-0442, USA.

Abstract

 

Haemonchus contortus is a blood-sucking abomasal parasite responsible for major losses to small ruminant producers worldwide. The recent increase in populations of c resistant parasites has produced a demand for alternative control methods. An orange oil emulsion that has shown activity against plant parasitic nematodes and H. contortus in vitro was assessed for activity against H. contortus in a gerbil model and in the natural ovine host. In gerbil experiments, animals were infected with 600 infective third stage (L3) H. contortus larvae. In one experiment, gerbils were treated with 600 milligrams per kilogram bodyweight (mg/kgBW) orange oil once or daily for 5 days. In a second experiment, gerbils were treated with 1200mg/kgBW orange oil once or daily for 5 days. On Day 9 post-infection, gerbils were killed, their stomachs removed, and the worms counted. The 600mg/kgBW dosage caused 7% and 62.6% parasite reduction compared to a control group when given once or daily for 5 days, respectively. The 1200mg/kgBW dosage of orange oil caused 25% and 87.8% parasite reduction compared to a control group when given once or daily for 5 days, respectively. The difference between the multiple treatment and control group were significant at both dosages (P<0.005). In the sheep trial, 18 lambs were orally inoculated with 10,000 L3 H. contortus. One month later, two groups of six lambs each were dosed with 600mg/kg BW orange oil either once or daily for 3 days. Fecal egg counts were monitored daily starting on the first day of treatment (Day 0) and continuing for 14 days. Results showed that a single dose of the product caused high fecal egg count reduction (97.4%) compared to control sheep. Egg counts were significantly reduced by Day 2 (P<0.0001). Thus, the orange oil emulsion may potentially be useful in the control of ovine haemonchosis. Copyright © 2010 Elsevier B.V. All rights reserved.

 

Abstract

 

 

 

Haemonchus contortus is a blood-sucking abomasal parasite responsible for major losses to small ruminant producers worldwide. The recent increase in populations of anthelmintic resistant parasites has produced a demand for alternative control methods. An orange oil emulsion that has shown activity against plant parasitic nematodes and H. contortus in vitro was assessed for activity against H. contortus in a gerbil model and in the natural ovine host. In gerbil experiments, animals were infected with 600 infective third stage (L3) H. contortus larvae. In one experiment, gerbils were treated with 600 milligrams per kilogram bodyweight (mg/kgBW) orange oil once or daily for 5 days. In a second experiment, gerbils were treated with 1200mg/kgBW orange oil once or daily for 5 days. On Day 9 post-infection, gerbils were killed, their stomachs removed, and the worms counted. The 600mg/kgBW dosage caused 7% and 62.6% parasite reduction compared to a control group when given once or daily for 5 days, respectively. The 1200mg/kgBW dosage of orange oil caused 25% and 87.8% parasite reduction compared to a control group when given once or daily for 5 days, respectively. The difference between the multiple treatment and control group were significant at both dosages (P<0.005). In the sheep trial, 18 lambs were orally inoculated with 10,000 L3 H. contortus. One month later, two groups of six lambs each were dosed with 600mg/kg BW orange oil either once or daily for 3 days. Fecal egg counts were monitored daily starting on the first day of treatment (Day 0) and continuing for 14 days. Results showed that a single dose of the product caused high fecal egg count reduction (97.4%) compared to control sheep. Egg counts were significantly reduced by Day 2 (P<0.0001). Thus, the orange oil emulsion may potentially be useful in the control of ovine haemonchosis. Copyright © 2010 Elsevier B.V. All rights reserved.

[Little Bo Boop]

Wow, thanks for posting that. I'm always looking at natural alternatives for parasite control...I know orange oil is pretty amazing stuff. I've been thinking about using it on my dogs for flea control. Had a flea problem this year for the first time in 10 years driving me and the dogs crazy! I've already dosed twice with Frontline (its' always worked!) but not this time....So maybe a little orange oil for the dogs and the sheep ;-)

 

BEtty

[Bill Fosher]

Any information on the LD50 of orange oil? Tobacco is an incredibly effective natural dewormer; the problem is that in order to kill the worms you have to sicken the sheep.

[Mark Billadeau]

Bill,

 

so far all I've been able to find on the oral toxicity of orange oil, or limonene (>90% of orange oil composition) has been multiple orange oil references for rats (4,400mg/kg) or mice (5,600mg/kg).

 

Mark