Mark Billadeau Posted November 18, 2021 Report Share Posted November 18, 2021 Susceptibility of sheep to experimental co-infection with the ancestral lineage of SARS-CoV-2 and its alpha variant BioRxiv preprint 17 Nov 2021 Quote we performed in vitro and in vivo studies which consisted of infection of ruminant-derived cell cultures and experimental challenge of sheep to investigate their susceptibility to SARS-CoV-2. Quote experimental challenge of sheep demonstrated limited infection with viral RNA shed in nasal and oral swabs primarily at 1-day post challenge (DPC), and also detected in the respiratory tract and lymphoid tissues at 4 and 8 DPC. Sero-reactivity was also observed in some of the principal infected sheep but not the contact sentinels, indicating that transmission to co-mingled naive sheep was not highly efficient Sheep did become infected after a direct challenge of virus (Wuhan or Wuhan plus Alpha variants); however, the sheep not challenged with virus but house with the challenged sheep did not become infected. This was a very small study, only 10 sheep. Quote Link to comment Share on other sites More sharing options...
amc Posted November 18, 2021 Report Share Posted November 18, 2021 Interesting. Where did this study take place? Can this be classified as 'gain of function' research? Amy Quote Link to comment Share on other sites More sharing options...
Mark Billadeau Posted November 18, 2021 Author Report Share Posted November 18, 2021 This study was performed at the Biosecurity Research Institute at KSU and it was definitely not a gain of function study; the virus was not manipulated to alter the virus. The animals were just exposed to the virus. Quote Link to comment Share on other sites More sharing options...
amc Posted November 19, 2021 Report Share Posted November 19, 2021 My 'gain-of-function' crack was a little dig to some who disparage a lot of the science around this pandemic ;-) but I am somewhat concerned about zoonoses in general, given that dangerous-to-humans mutations can and do originate when viruses skip across species. Have you come across any more research on dog-to-human (and vice versa) SARS Co-V-2 transmission? Quote Link to comment Share on other sites More sharing options...
Mark Billadeau Posted November 19, 2021 Author Report Share Posted November 19, 2021 I’ve not seen and new studies in dogs. The previously posted studies indicated dogs can be infected (from infected humans or in a small virus challenge study). The dogs in the challenge study did not shed virus (were unlikely to transmit the virus to other dogs or humans). Quote Link to comment Share on other sites More sharing options...
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