iLLt3cK Posted October 20, 2016 Report Share Posted October 20, 2016 Both of my boys have been recently diagnosed with heart murmurs which has been confirmed as mitral valve regurgitation referred to as myxomatous mitral valve degeneration (MVVD). Luckily we seem to have caught it early as both of their hearts are within normal range despite the confirmed diagnosis. Took them to see a cardiologist @ Texas A&M and the experience was great. During the visit the cardiologist referred to a recently completed trial that I did some research on below: There have been two veterinary medicine trials within the past couple of years that have proven that pimobendan (vetmedin) can significantly increase a dog's life span and quality of life as compared to an ACE inhibitor (like benazepril / enalapril) which have been the gold standard prescription once a dog has entered the CHF stage (algongside other supplemental drugs like furosemide, beta blockers, etc). This was discovered in the QUEST trial. https://www.epictrial.com/epic-trial/faqs/#whatisquest Not only that, but it gets better! Following the QUEST trial they then posed the question, "Well, if pimobendan is this effective at elongating and improving a dogs life that has entered CHF - does it help stave off CHF in a dog with MVVD that is pre-clinical (not showing symptoms like coughing, fluid build up, significantly enlarged heart)? Turns out, YES IT DOES! https://www.epictrial.com/epic-trial/faqs/#whatisepic Here's the cliff notes of the latest study which is very promising: "Prolongation of preclinical period by approximately 15 months represents substantial clinical benefit." https://www.ncbi.nlm.nih.gov/pubmed/27678080 Would be interested to hear if anyone else was aware of this new information and what you all think. Hoping to pass this on to give you & yours a better shot when dealing with MVVD / CHF. Here's a link to the full EPIC study that went in the Journal of Veterinary Internal Medicine: http://onlinelibrary.wiley.com/doi/10.1111/jvim.14586/pdf Quote Link to comment Share on other sites More sharing options...
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