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Trifexis


ItsADogsLyfe
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I've used it. It's a combination of Interceptor (milbemycin) and Comfortis (spinosad). We sell it here at the hospital and occasionally we hear of tummy upset with the Comfortis but not that many. If you use Comfortis and Interceptor, it's MUCH cheaper to go with Trifexis. The Trifexis is only about 15% more than the Comfortis.

 

Michelle

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I have a customer that came in yesterday that gave it to her dog on Tues. Not a flea on her. It cost her $90 for a 6 mos supply 10#-20# dog. I just paid $86 for 6 mos of Frontline that did absolutely nothing for the fleas. I pay another $33 a month for heartworm for 6 mos supply. So that would save me almost $30 if it works well and has no bad side effects.

Sue, let me know how your daughter likes it.

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Joan - I give Interceptor all year around but only use flea treatment when needed. This year, I only gave Comfortis twice, both times because we were taking the dogs somewhere where fleas are prevalent. For some reason, we just have not seemed to have fleas here this year, and we don't find ticks on our dogs here. (Knock on wood.) Frontline and then Advantage both ceased to work for us in prior years and that's why we tried the Comfortis, which works very well.

 

Lisa lives where fleas and ticks can be a year-round issue (she uses a tick collar like Preventic, I think) and so using this new product would probably save her quite a few dollars over the year.

 

Since I don't give Comfortis except occasionally most years, I will stick with Interceptor. I, too, am eager to hear how she likes it because it sounds like a good idea. I'll let you know!

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Comfortis works well and I will give it occasionally. But, the last time I gave it, two dogs vomitted about 10-15 minutes later. I was bummed because the stuff isn't cheap. Has anyone had any problems with stomach upset with Trifexis?

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Yes, Comfortis (spinosad) can cause vomiting. Trifexis is spinosad combined with interceptor so I'd guess vomiting is certainly an issue. When we recommend comfortis we tell people that they can safely split the dose (give 1/2 in the morning & then 1/2 in the evening) t minimize the likelihood of vomiting.

 

We don't prescribe Trifexis (at least not yet) so I don't know if splitting the dose would affect the heart worm part.

 

FYI, Elanco has been really good about refunding us for dogs that vomit Comfortis. Mary, you should tell your vet & they can give you a replacement pill for the 2 that vomited it up.

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A word of caution. I just recieved an email about a member of my agility club's dog, a GR, that passed away suddenly after going into seizures yesterday. The dog was not very old (probably less than 4 or 5). They are doing a necropsy to see if they can find out why but are suspecting that it was the new heartworm, Trifexis, that they started him on. Of course, the two could be completely unrelated, but it's something to think about.

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Spinosad lowers the seizure threshold in epileptic dogs. It also potentiates the toxicity of & should not be used in conjunction with ivermectin.

 

Since it is protein bound, it stays in the body for ~30 days. this can be a very bad thing if you have issues with it.

 

Unfortunately, it would not be surprising if the 2 were related.

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