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Denise Wall

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About Denise Wall

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  • Birthday 11/06/1953

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    http://www.stilhope.com
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  1. I finally got a chance to go through this video again trying to pay more attention to detail. Basically, my take on it is, as is obvious, it's not good to use high dose ivermectin (group 1). Lots of problems. In group 2, these dogs, different breeds and with their MDR1 status unknown, were already suspected of having retinal problems in association with regular heart worm meds alone or in association with other flea and tick products. Group 3 contains a "pure" group of dogs taking only regular dose HW meds but again, no info about the breeds or other info such as HDR1 status of the dogs. Group
  2. One main concern of mine from this presentation is the possibility that Comfortis and Trifexis (popular flea and tick preventatives) are inhibitors of p-glycoprotein, the protein produced by the MDR1 gene, and as such can increase ivermectin concentration 360%. See the slide at 59 seconds of the video. If true, this is concerning for all dogs on heart worm prevention. I think it's something that bears following.
  3. I am working on this. It's a pretty complicated subject actually, and reading and properly evaluating the scientific literature as well as trying to find personal accounts in breeds other than border collies (where the incidence is extremely low) will take some time. Most of the dog forums and personal accounts revolve around heart worm medicine and other commonly used meds such as acepropazime. I'm just trying to be thorough because it's important. I'm sorry it's taking so long.
  4. Rest in peace, Donald. You truly loved the working border collie.
  5. No problem Candy I was actually trying to convey that many evaluations of and support for health and genetic disease problems are going on all the time over many years with the ABCA Health and Genetics Committee and ABCA Board, even if they aren't all apparent to the membership right away. Many of these situations for research are complicated and involve many factors and careful consideration. We're trying to play the "long game," although that's sometimes hard to understand and accept when one has an immediate problem.
  6. I'm sure you probably didn't mean it this way, and believe me I'm not looking for personal thanks when I point this out, but as someone who's been on the ABCA Health and Genetics Committee for two decades, I hope people realize that this is not just the "first step" forward in improving information and education about the health and genetics of our breed. Many dedicated people have been involved for many years in this endeavor, even if their efforts haven't always been in the spotlight.
  7. Not to hijack this topic but since this keeps coming up: Although I originally wrote this dart board analogy to describe what I *think* might happen when working breeds are lost, it applies to trying to imagine how to keep the working gene pool healthy. I am a breeder (or was at least) and it's a very difficult to circle that square in real life. Many here will be familiar with this analogy already: Assume the border collie is the theoretical breed, where many strong workers existed in the original breeding pool and the need for their work was not lost or reduced over time but ins
  8. I've been in this a long time. I hear things and I know some things for sure. For example, in one case, a famous sire was tri. The dog's son off him was black and white. This black and white dog, also famous, was used *a lot* at stud. He never produced even one tri pup, not even when bred to tri bitches. When a dog sires 100 or 100s of pups, it starts to be outside the realm of genetic possibility that he is carrying the tri gene, which is recessive. Other times, pedigree "inaccuracies" in the past are common knowledge overseas, even though no one will repeat them in writing. I've also hea
  9. I have two points to add for interest. What's recorded on the pedigrees and used for the UK database may not actually represent the true parentage. Sorry, but true. In one of my late dog's pedigrees there were three wrong UK sires listed that I know of. It happens here too. AKC once did a study of pedigrees versus the true parentage and found a shocking percentage of inaccuracies. It doesn't matter if a dog was a popular sire (WRT passing on genetic disease through later line breeding) if no one breeds from the offspring. Sometimes that happens.
  10. I just heard of this and add my absolute shock and sadness to that of her so many other friends who knew her personally and from the internet. We will miss you so much Hilary.
  11. I can personally attest to the fact they really work. I've been using them on my 15 year old Mick for several months. He was having trouble on slick floors. I tried to put rugs everywhere I could, but he still found slick places to slip and fall. These toegrips have made a tremendous difference in his quality of life and my piece of mind. I would recommend them without reservation. Just get the right size and read the instructions. ETA No, he doesn't chew them off. They actually stay on amazingly well.
  12. Nobody started it yet so I guess I will. Goodbye my sweet, wonderful boy. You were a brilliant working dog and taught me so much. Stilhope Zeke (1999-2012):
  13. TEC, I'm a bit behind on this topic but wanted to have my say. One of the videos of a mild episode of BCC on this site is of my dog Zeke: FWIW, I am a scientist with a PhD in biochemistry as well a clinical laboratory degree (BS MT(ASCP)) and experience in laboratory medicine. So even though I wasn't wearing a white lab coat, I have one Blood and other clinical parameters had been tested on this dog in the past and were all normal. Also, FWIW, I did not induce this episode. Sometimes, even after years of experience, it's difficult to tell what will precipitate an episode. In t
  14. I'm a bit late to this thread but I just want to say something others are saying but hopefully a little differently. Think of the working border collie as needing to be bred for all the right pieces to fit together properly. The checks and balances of that system of careful selection of traits makes the dog whole. It doesn't always work out perfectly, but the goal needs to be maximal effort at keeping all the pieces there and together just right or the breed starts to fall apart. For this breed, that can only be accomplished by selecting for stockworking ability. If one selects for only some
  15. I don't run with that crowd so I have to ask, are they breeding those kick butt Redtop obedience dogs or going back to Redtop for their next dogs?
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